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The minimal physiologically‐based pharmacokinetic ( mPBPK ) models that are used in ATLAS mPBPK. ( a ) mPBPK model for small molecules. ( b ) mPBPK model for large molecules with no target binding. ( c ) mPBPK model for large molecules with target binding in plasma (interstitial fluid). ( d ) mPBPK model for large molecules with target binding in peripheral tissues. Parameters' names and typical values are shown in Table . EV, extravascular; IV, intravenous; PO, oral.

Journal: CPT: Pharmacometrics & Systems Pharmacology

Article Title: ATLAS mPBPK: A MATLAB‐Based Tool for Modeling and Simulation of Minimal Physiologically‐Based Pharmacokinetic Models

doi: 10.1002/psp4.12441

Figure Lengend Snippet: The minimal physiologically‐based pharmacokinetic ( mPBPK ) models that are used in ATLAS mPBPK. ( a ) mPBPK model for small molecules. ( b ) mPBPK model for large molecules with no target binding. ( c ) mPBPK model for large molecules with target binding in plasma (interstitial fluid). ( d ) mPBPK model for large molecules with target binding in peripheral tissues. Parameters' names and typical values are shown in Table . EV, extravascular; IV, intravenous; PO, oral.

Article Snippet: In this tutorial, we present a MATLAB‐based tool for the modeling and simulation of mPBPK models (ATLAS mPBPK).

Techniques: Binding Assay, Clinical Proteomics

Concordance of simulated ATLAS mPBPK small‐molecule model values based on pharmacokinetic data of beta‐lactams. Figure is not an output of ATLAS mPBPK but was constructed by processing ATLAS mPBPK simulation output using MATLAB.

Journal: CPT: Pharmacometrics & Systems Pharmacology

Article Title: ATLAS mPBPK: A MATLAB‐Based Tool for Modeling and Simulation of Minimal Physiologically‐Based Pharmacokinetic Models

doi: 10.1002/psp4.12441

Figure Lengend Snippet: Concordance of simulated ATLAS mPBPK small‐molecule model values based on pharmacokinetic data of beta‐lactams. Figure is not an output of ATLAS mPBPK but was constructed by processing ATLAS mPBPK simulation output using MATLAB.

Article Snippet: In this tutorial, we present a MATLAB‐based tool for the modeling and simulation of mPBPK models (ATLAS mPBPK).

Techniques: Construct

Demonstration of ATLAS mPBPK large‐molecule model based on PK data of Trastuzumab (target binding in peripheral tissues) and Mavrillimumab (target binding in plasma) for a range of doses. Figures are not an output of ATLAS mPBPK but were constructed by processing ATLAS mPBPK simulation output using MATLAB. c‐TMDD, Target mediated drug disposition in plasma (central); hr, hour; mPBPK, minimal physiologically‐based pharmacokinetic modeling; p‐TMDD, target‐mediated drug disposition in peripheral tissues.

Journal: CPT: Pharmacometrics & Systems Pharmacology

Article Title: ATLAS mPBPK: A MATLAB‐Based Tool for Modeling and Simulation of Minimal Physiologically‐Based Pharmacokinetic Models

doi: 10.1002/psp4.12441

Figure Lengend Snippet: Demonstration of ATLAS mPBPK large‐molecule model based on PK data of Trastuzumab (target binding in peripheral tissues) and Mavrillimumab (target binding in plasma) for a range of doses. Figures are not an output of ATLAS mPBPK but were constructed by processing ATLAS mPBPK simulation output using MATLAB. c‐TMDD, Target mediated drug disposition in plasma (central); hr, hour; mPBPK, minimal physiologically‐based pharmacokinetic modeling; p‐TMDD, target‐mediated drug disposition in peripheral tissues.

Article Snippet: In this tutorial, we present a MATLAB‐based tool for the modeling and simulation of mPBPK models (ATLAS mPBPK).

Techniques: Binding Assay, Clinical Proteomics, Construct